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测定妥舒沙星的体内外抗菌活性。以同类氟喹诺酮类及其他抗菌药物为对照，测定了６８９株临床分离菌对药物的敏感性，结果显示，妥舒沙星对需氧革兰氏阳性球菌（除ＭＲＳＡ外）均有良好的抗菌作用，对金葡球菌、肺炎球菌和溶血性链球菌的抗菌活性高；妥舒沙星对需氧革兰氏阴性菌具强大的抗菌作用，对肠杆菌科细菌、流感杆菌和淋球菌的抗菌作用尤强；妥舒沙星对脆弱拟杆菌等厌氧菌亦具良好抗菌作用。妥舒沙星对需氧革兰氏阳性球菌及厌氧菌的作用明显优于环丙沙星、氧氟沙星和诺氟沙星，对需氧革兰氏阴性杆菌的作用与其他受试氟喹诺酮类相仿。妥舒沙星对小鼠实验性细菌感染具有明显保护作用，口服或静注妥舒沙星对金葡球菌的体内抗菌作用明显优于环丙沙星；对大肠埃希氏菌的抗菌作用优于或与环丙沙星相似；对铜绿假单胞菌的作用与环丙沙星相似。
Determination of tosufloxacin in vitro and in vivo antibacterial activity. To similar fluoroquinolones and other antibacterials as a control, determination of 689 strains of clinical isolates of drug sensitivity, the results show that tosufloxacin on aerobic gram-positive cocci (except MRSA) have good antibacterial The role of Staphylococcus aureus, pneumococcus and hemolytic streptococcus antibacterial activity; tosufloxacin aerobic gram-negative bacteria with a strong antibacterial effect on Enterobacteriaceae, Influenza and Neisseria gonorrhoeae antibacterial Especially strong role; tosufloxacin Bacteroides fragilis and other anaerobic bacteria also have good antibacterial activity. The effect of tosufloxacin on aerobic gram-positive cocci and anaerobic bacteria was significantly better than that of ciprofloxacin, ofloxacin and norfloxacin. The effect of tosufloxacin on aerobic gram-negative bacilli was similar to that of other tested Fluoroquinolones similar. Toshusaroxacin has obvious protective effect on experimental bacterial infection in mice, oral or intravenous injection of tosufloxacin against Staphylococcus aureus was significantly superior to that of ciprofloxacin in vivo antibacterial effect on Escherichia coli At or similar to ciprofloxacin; Pseudomonas aeruginosa and ciprofloxacin role similar.