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目的探讨临床上钳刮术前应用米非司酮配伍米索前列醇终止10~14周妊娠的临床效果和安全性。方法选取2010年7月~2012年12月我院110例自愿要求引产的10~14周妊娠的妇女,拟行钳刮术,随机分为两组,观察组术前给予米非司酮配伍米索前列醇用药;对照组在术前行羊膜腔内注射利凡诺100mg。干预后记录用药时间、宫缩发动时间、胎儿胎盘娩出时间等。结果随访结果显示,两组完全流产率比较差异具有显著性(P<0.05);术后两组在子宫出血、胎盘胎膜残留方面差异有显著性(P<0.05),宫颈撕裂发生无显著性差异(P>0.05)。结论钳刮术前应用米非司酮配伍米索前列醇终止10~14周妊娠,具有完全流产率高、胎盘胎膜残留率和子宫出血发生率少等优点,克服了单一用钳刮术所致的不良结局,具有广阔的临床应用前景。
Objective To investigate the clinical efficacy and safety of mifepristone and misoprostol in terminating 10-14 weeks gestation before forceps curettage. Methods From July 2010 to December 2012 in our hospital 110 cases of voluntary induction of labor of women of 10 to 14 weeks of pregnancy, the proposed forceps curettage, were randomly divided into two groups, the observation group preoperatively given mifepristone compatibility with rice Supramostat medication; control group preoperative amniotic injection of rivanol 100mg. Record medication time after intervention, uterine contracting time, fetal placenta delivery time and so on. Results The follow-up results showed that the rate of complete abortion was significantly different between the two groups (P <0.05). There was significant difference between the two groups in uterine bleeding and residual placental membranes (P <0.05) Sex differences (P> 0.05). Conclusions The use of mifepristone and misoprostol to terminate 10-14 weeks gestation before forceps curettage has the advantages of complete abortion rate, residual rate of placental membranes and less incidence of uterine bleeding, Caused by adverse outcomes, has a broad clinical application prospects.