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目的 研究肝细胞肝癌 (HCC)患者预后与肿瘤的病理形态特征、PCNA指数及DNA指数的关系。方法 分析 5 1例中等分化HCC患者的临床、随访资料及病理形态特征 ;应用免疫组织化学方法检测其PCNA阳性指数 ;应用图像分析仪进行DNA指数测量。结果 癌灶单个 ,直径≤ 5cm ,无癌栓、无肿瘤旁子灶及癌性坏死患者预相对较好 ;DNA整数倍体预后好于非整倍体 ,非整倍体中DI<1.5者又好于 >1.5者 ;PCNA指数越高 ,患者预后越差 ;DI与PCNA指数有一定的相关 ,且两者与病理形态特征间也有关联。结论 进行病理形态学和PCNA、DNA指数的前瞻性综合分析是评估患者术后是否高危复发及其预后的有效方法
Objective To study the relationship between the prognosis of hepatocellular carcinoma (HCC) patients and the pathological features, PCNA index and DNA index. Methods The clinical, follow-up and pathological features of 51 moderately-differentiated HCC patients were analyzed. The positive rate of PCNA was detected by immunohistochemistry. The DNA index was measured by image analyzer. Results A single tumor with a diameter of 5 cm or less had no tumor thrombus and no adjacent tumor and no necrosis. The prognosis of DNA multiploid aneuploidy was better than that of aneuploidy, DI was less than 1.5 in aneuploidy Better than> 1.5; the higher the PCNA index, the worse the patient’s prognosis; DI and PCNA index have some correlation, and the two are also associated with the pathological features. Conclusions The prospective comprehensive analysis of pathomorphology, PCNA and DNA index is an effective method to evaluate the high risk of recurrence and its prognosis in patients after operation