本研究以微核为观察指标,探讨氯霉素对Wistar大鼠胎肝多染红细胞(PCE)染色体的影响。大鼠分20、40和160mg/kg三个剂量组,对受孕d13经腹膜腔注射一次给药。同时设一个阳性对照组,注射环磷酰胺30mg/kg,阴性对照组注射等量二甲亚砜溶剂,给药后18h处死母鼠,取胎肝制片,每只孕鼠计数1000个PCE。 In this study, micronucleus was used as an index to investigate the effect of chloramphenicol on chromosomes of fetal liver polychromatic erythrocytes (PCE) in Wistar rats. The rats were divided into three groups of 20, 40 and 160 mg / kg. The rats were d13 injected intraperitoneally once a day for conception. At the same time, a positive control group was injected with cyclophosphamide at 30mg / kg. The negative control group was injected with the same amount of dimethylsulfoxide solvent. After the administration, the female rats were sacrificed at 18h. The fetal liver was taken and the number of each PCE was counted.