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首先利用阳离子开环聚合合成了超支化聚缩水甘油醚(HPG),然后通过酯化反应制备了低接枝率的大分子引发剂HPG-Br,并进一步引发甲基丙烯酸-2-(N,N-二甲氨基)乙酯(DMAEMA)单体的原子转移自由基聚合,合成了低接枝率的双亲水性超支化接枝共聚物HPG-g-PDMAEMA,用1HNMR和GPC对聚合物结构进行了表征.并采用芘荧光探针法,HNMR和DLS研究了HPG-g-PDMAEMA在不同pH水溶液中的组装行为.以1香豆素102为模型药物研究了HPG-g-PDMAEMA聚合物在不同pH条件下的药物释放行为,发现在pH连续振荡刺激下HPG-g-PDMAEMA聚合物胶束对药物分子能实现部分“可逆”的释放和再包载.
Firstly, the hyperbranched polyglycidyl ether (HPG) was synthesized by cationic ring-opening polymerization. Then HPG-Br with low grafting rate was prepared by esterification reaction, and then 2- (N, N-dimethylamino) ethyl methacrylate (DMAEMA) monomer by atom transfer radical polymerization, synthesis of a low grafting rate of the two hydrophilic hyperbranched graft copolymer HPG-g-PDMAEMA, 1H NMR and GPC polymer structure HPG-g-PDMAEMA in different pH aqueous solutions was investigated by pyrene fluorescence probe method, HNMR and DLS.Using HPMA as a model drug, The results showed that HPG-g-PDMAEMA polymer micelles could partially and “reversibly” release and repackage the drug molecules under continuous pH stimulation.