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目的 通过对慢性粒细胞白血病 (CML )预后的检测 ,指导 CML治疗方案的选择。方法 应用 Cox模型对 5 9例 CML患者进行回顾性分析。结果 高危组 32例 ,中危组 2 7例 ,无一例低危组 ,高、中危组 2年急变率分别为 2 8%和 7% ,3年急变率分别为 5 3%和 14%。结论 在影响预后的许多因素中 ,脾脏大小及末梢中原始细胞的百分数是最危险的因素 ,红细胞压积对 46岁以下患者的预后亦有意义 ,而血小板计数对判断 CML 预后在高、中危组中差异并不显著。
Objective To detect the prognosis of chronic myeloid leukemia (CML) and guide the choice of CML regimen. Methods Fifty-nine CML patients were retrospectively analyzed by Cox model. Results There were 32 cases in high risk group and 27 cases in intermediate risk group. None in low risk group was 2 8% and 7% in high and intermediate risk group respectively. The 3 year acute abortion rates were 53% and 14% respectively. Conclusions Among many factors affecting the prognosis, the spleen size and the percentages of blasts in the distal end are the most dangerous factors. The hematocrit is also significant for the prognosis of patients under 46 years of age, and the platelet count is high in predicting the prognosis of CML The difference in the group was not significant.