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目的:分析神经生长因子(NGF)在人脑胶质瘤中的表达情况,并分析其余患者肿瘤组织病理分级和预后间的关系。方法:回顾性分析2014年1月~2015年1月间我院接诊的44例脑胶质瘤患者的临床资料,以分析NGF表达情况与患者病理分级与预后间的相关性。结果:胶质瘤组患者脑组织中的NGF核阳性率显著高于对照组(P<0.05);A组患者脑组织中的NGF核阳性率显著低于B组患者(P<0.05);A、B组患者中NGF表达阳性患者的中位生存时间显著低于NGF表达为阴性者(P<0.05)。结论:人脑胶质瘤患者中NGF的表达与其病理组织分级、预后有着明显的相关性。
OBJECTIVE: To analyze the expression of nerve growth factor (NGF) in human glioma and to analyze the relationship between tumor histopathological grade and prognosis in the remaining patients. Methods: The clinical data of 44 patients with gliomas admitted from January 2014 to January 2015 in our hospital were analyzed retrospectively to analyze the correlation between the expression of NGF and pathological grade and prognosis. Results: The positive rate of NGF nucleus in glioma group was significantly higher than that in control group (P <0.05). The positive rate of NGF nucleus in group A was significantly lower than that in group B (P <0.05). A . The median survival time of patients with positive NGF expression in group B was significantly lower than those with negative expression of NGF (P <0.05). Conclusion: The expression of NGF in glioma patients is obviously correlated with its pathological grade and prognosis.