论文部分内容阅读
盐酸格雷西龙是南京军事研究所研制的第四类新药。本文采用随机分组、自身对照、交叉设计的方法，对37例恶性肿瘤化疗病人进行预防呕吐的临床观察，比较盐酸格雷西龙与进口康泉及国产灭吐灵止吐疗效反应。联合化疗方案为含有顺铂（80mg／m2）或阿霉素（40mg／m2），盐酸格雷西龙或康泉3mg加生理盐水30～50ml稀释，化疗前5分钟静脉推注，第1、3天；灭吐灵20mg，化疗当日肌注，每日2次。每一病人用同一方案化疗2周期。结果表明盐酸格雷西龙注射液的止吐有效率（86．5％）与康泉止吐率（80％）相似，明显好于灭吐灵对照组（有效率41．2％）。其毒副作用与康泉相似，主要为头痛头晕、便秘及腹部不适。头痛头晕发生率为5．4％，便秘及腹部不适为8．1％，无灭吐灵的锥体外系反应。作者认为盐酸格雷西龙是一个安全、有效、经济的预防化疗引起的消化道反应的国产止吐药物。
Grassione hydrochloride is the fourth new drug developed by Nanjing Military Research Institute. This article randomized grouping, self-control, cross-design method, 37 cases of malignant tumor chemotherapy patients to prevent vomiting clinical observation, compare hydrochloric acid gracilil with imported Kangquan and homemade antiemetic antiemetic efficacy response. Combined chemotherapy regimen containing cisplatin (80mg/m2) or adriamycin (40mg/m2), Grassione hydrochloride or Kangquan 3mg plus normal saline 30-50ml diluted, intravenous injection 5 minutes before chemotherapy, 1st, 3rd Days; spit Ling 20mg, intramuscular injection of chemotherapy the same day, 2 times a day. Each patient used the same regimen for 2 cycles of chemotherapy. The results showed that anti-emetic efficacy (86.5%) of Gracillin hydrochloride injection was similar to Kangquan antiemetic rate (80%), which was significantly better than that of Qutuling control group (effective rate 41.2%). Its toxic and side effects are similar to those of Kangquan, mainly due to headache, dizziness, constipation and abdominal discomfort. The incidence of headache dizziness was 5.4%, constipation and abdominal discomfort was 8.1%, and there was no extrapyramidal response to methazobulin. The authors believe that gexicillin hydrochloride is a safe, effective, and economical domestic antiemetic drug to prevent chemotherapy-induced gastrointestinal reactions.