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朊病毒蛋白有两种形式,即PrPC和PrPSc。PrPC是正常的细胞蛋白;而PrPSc是PrPC的异构体,具有致病性。大量的证据表明朊病毒是由PrPC错误折叠从而转变成PrPSc的,朊病毒病的发生与发展与PrPC转变成PrPSc密切相关,朊病毒病属于蛋白质构象病。本文将着重叙述PrPC转化成PrPSc的各种影响因素。
There are two forms of prion protein, PrPC and PrPSc. PrPC is a normal cellular protein; PrPSc is an isoform of PrPC with pathogenicity. There is a lot of evidence that the prion is misfolded by PrPC and thus converted into PrPSc. The occurrence and development of prion disease is closely related to PrPSc, Prion disease belongs to protein conformation disease. This article will focus on the various factors that translate PrPC into PrPSc.