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目的:观察米非司酮联合中药内服外敷治疗陈旧性宫外孕的临床疗效。方法:将68例陈旧性宫外孕患者随机分为2组,对照组34例予米非司酮治疗;治疗组34例在对照组治疗的基础上加用化瘀消癥汤内服及消癥散外敷,统计2组患者临床疗效,评价2组治疗前后中医证候积分、包块直径、血液流变学变化,记录治疗期间不良反应。结果:总有效率治疗组为97.1%,对照组为61.8%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者中医证候积分、包块直径均较治疗前明显降低(P<0.05),且治疗组两项指标降低程较对照组更显著(P<0.05)。治疗后,2组患者全血高切黏度、全血中切黏度、全血低切黏度、血浆黏度等指标均较治疗前降低(P<0.05),且治疗组上述指标改善较对照组更显著(P<0.05)。不良反应率治疗组为5.9%,对照组为26.5%,2组比较,差异有统计学意义(P<0.05)。结论:应用化瘀消癥汤联合中药外敷与米非司酮治疗陈旧性宫外孕疗效显著,且用药安全。
Objective: To observe the curative effect of mifepristone combined with traditional Chinese medicine and external application on the treatment of old ectopic pregnancy. Methods: 68 cases of old ectopic pregnancy were randomly divided into two groups, the control group of 34 patients treated with mifepristone; the treatment group of 34 patients in the control group based on the treatment plus the Huayu Xiaozheng decoction and Xiaozheng San external application . The clinical efficacy of the two groups were statistically evaluated. The TCM syndrome scores, mass diameter and hemorheology were evaluated before and after treatment in the two groups. The adverse reactions during the treatment were recorded. Results: The total effective rate was 97.1% in the treatment group and 61.8% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the score of TCM syndromes and the diameter of mass in two groups were significantly lower than those before treatment (P <0.05), and the two indexes in the treatment group decreased more significantly than those in the control group (P <0.05). After treatment, the indexes of whole blood viscosity, whole blood shear viscosity, whole blood low shear viscosity, plasma viscosity and so on were lower than those before treatment (P <0.05), and the above indexes in the treatment group improved more significantly than those in the control group (P <0.05). Adverse reaction rate was 5.9% in the treatment group and 26.5% in the control group. There was significant difference between the two groups (P <0.05). Conclusion: The application of Huayu Xiaozheng Decoction combined with traditional Chinese medicine and mifepristone in the treatment of obsolete ectopic pregnancy has significant curative effect and is safe for medication.