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目的:研究miR-199b在宫颈癌组织中的表达及其临床意义。方法:利用实时定量PCR方法检测miR-199b在35例宫颈癌组织中的表达情况;采用χ2检验分析miR-199b表达水平与各临床病理参数之间的关系;用Kaplan-Meier法分析miR-199b表达与宫颈癌患者生存期之间的关系。结果:与癌旁组织相比较,在35例肿瘤组织中,27例miR-199b高表达。miR-199b低表达患者平均生存时间为54.38个月(95%CI:42.90～65.85),miR-199b高表达患者平均生存时间33.48个月(95%CI:25.75～41.20)。miR-199b在宫颈癌组织中的表达水平与患者的无进展生存率明显相关,P=0.031。结论:miR-199b表达高的患者预后较差。miR-199b可能是预测宫颈癌预后的标志。
Objective: To study the expression of miR-199b in cervical cancer and its clinical significance. Methods: The expression of miR-199b in 35 cases of cervical cancer was detected by real-time PCR. The relationship between the expression of miR-199b and the clinicopathological parameters was analyzed by Chi-square test. The expression of miR-199b Relationship between expression and survival of cervical cancer patients. Results: 27 cases of miR-199b were highly expressed in 35 tumor tissues compared with adjacent tissues. The average survival time of patients with low expression of miR-199b was 54.38 months (95% CI: 42.90-65.85), and the average survival time of patients with high miR-199b expression was 33.48 months (95% CI: 25.75-41.20). The expression level of miR-199b in cervical cancer was significantly correlated with the progression-free survival (P = 0.031). Conclusion: Patients with high miR-199b expression have a poor prognosis. miR-199b may be a prognostic marker of cervical cancer.