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目的:从临床的角度观察、探讨丹参川芎嗪在治疗肾病综合症患者的临床意义。方法:临床随机选择24例原发性肾病综合症患者在传统激素、免疫抑制剂治疗基础上,加用丹参川芎嗪治疗,与对照组比较,观察其尿蛋白、尿量、血浆白蛋白、尿素氮、血肌酐等的变化。结果:24例丹参川芎嗪治疗组追踪观察8周,与对照组相比在治疗过程中尿蛋白明显下降,尿蛋白转阴疗程缩短,血浆白蛋白回升在治疗第4周后有明显统计学意义(p<0.01),两组治疗后比较血甘油三脂、胆固醇恢复正常无统计学意义。结论:丹参川芎嗪与激素联合治疗肾病综合征可起到协同积极的作用,值得临床借鉴。
Objective: To observe the clinical significance of ligustrazine injection in the treatment of patients with nephrotic syndrome. Methods: Twenty-four patients with primary nephrotic syndrome were randomly selected on the basis of traditional hormones and immunosuppressive drugs and treated with ligustrazine. Compared with the control group, urinary protein, urine output, plasma albumin, urea Nitrogen, serum creatinine and other changes. Results: Twenty-four cases of Ligustrazine TMP group were followed up for 8 weeks. Compared with the control group, urinary protein decreased significantly, urinary protein negative conversion course shortened, and plasma albumin recovery significantly increased after 4 weeks of treatment (p <0.01). After treatment, blood triglyceride and cholesterol returned to normal without statistical significance. Conclusion: The combination therapy of Ligustrazine and Hormone can play a synergistic and active role in nephrotic syndrome, which is worthy of clinical reference.