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采用“混合材料-挤压成粒-滚转成球”的一步法制粒机(marumerizer)制备了扑热息痛微球,观察到软材在机中停留时间越长,大球粒子(直径大于14目)形成的比例越高。根据两细粒碰撞聚集成球的假说,认为可按二级速度方程式,推算出剩余细粒的倒数1/(s-x)与机中停留时间(t)呈线性关系,实验证实了这种关系(r=0.999)。实验还证明了滚转时间越长,球粒中药物的释放速度越慢。溶出速率试验表明,这种球粒中药物的释放符合Higuch的平方根函数关系。
The paracetamol microspheres were prepared by a marumerizer of “mixed material - extrusion granulation - rolling into a ball”. The longer the residence time of the soft material was observed in the machine, the bigger the spherical particles (diameter> 14 mesh) The higher the proportion of formation. According to the hypothesis that two fine particles collide and aggregate into a sphere, it is considered that the relationship between the reciprocal 1 / (sx) of the remaining fine particles and the residence time (t) in the machine can be inferred from the second-order velocity equation. r = 0.999). Experiments also show that the longer the rollover time, the slower the drug release in the pellet. Dissolution rate tests showed that the release of the drug in this pellet conformed to the square root function of Higuch.