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从哺乳期开始建立缺锌（ＺＤ）高锌（ＺＨ）和对照（ＡＬ）幼鼠模型研究饲料锌含量对幼鼠海马发育和学习记忆的影响。结果、（１）ＺＤ、ＺＨ组幼鼠体重增长值、饲料效价均低于ＡＬ组（Ｐ＜０．０１）；（２）血清锌和海马锌含量ＺＤ组明显低于而ＺＨ组明显高于ＡＬ组；（３）海马锥体细胞ＤＮＡ含量ＺＤ组明显低于ＡＬ组，ＺＨ组与ＡＬ组无差异；（４）兴奋性和抑制性基氨酸总量ＺＤ、ＺＨ组均高于ＡＬ组，以谷氨酸和γ氨基丁酸差异最显著；（５）ＺＤ、ＺＨ组主动回避反应习得率均明显低于ＡＬ组；（６）ＺＤ、ＺＨ组海马长时程增强诱发率为０，ＡＬ组为１００％；（７）海马神经元突触小泡ＺＤ组明显减少，而ＺＨ组则突触小泡破裂，海马神经元、胶质细胞均有不同程度变性坏死，上述结果提示：从哺乳期开始摄入缺锌、高锌饲料均可影响幼鼠海马发育和学习记忆。
To study the effect of dietary zinc on the hippocampal development and learning and memory of infant rats from the beginning of lactation to establish a zinc deficient (ZD) high zinc (ZH) and control (AL) young rat model. The results showed that: (1) ZD and ZH groups showed lower weight gain and feed titer than the AL group (P <0.01); (2) Zinc and serum zinc levels in ZD and ZH group were significantly lower than those in ZH group (3) The content of DNA in hippocampal pyramidal cells in ZD group was significantly lower than that in AL group, there was no difference between ZH group and AL group. (4) The total excitatory and inhibitory amino acids in ZD group and ZH group were higher than those in AL group Group, glutamate and γ-aminobutyric acid were the most significant differences; (5) ZD, ZH group active avoidance learning rate were significantly lower than AL group; (6) ZD, ZH hippocampal long-term potentiation induction rate was 0, AL group was 100%; (7) hippocampal neuronal synaptic vesicles ZD group was significantly reduced, while ZH group synaptic vesicle rupture, hippocampal neurons, glial cells have varying degrees of degeneration and necrosis, the above results suggest : From the beginning of lactation intake of zinc deficiency, high zinc feed can affect the hippocampus development and learning and memory in young rats.