【摘 要】
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The porous HA/BaTiO3 ceramics have the potential to exhibit superior capabilities to promote bone in-growth.However,there are few reports on in vivo studies.Here,we fabricated bio-inspired porous HA/BaTiO3 composites for bone repair via freeze-casting.The
【机 构】
：
Department of Stomatology,Third Xiangya Hospital,Central South University,Changsha 410013,China
论文部分内容阅读
The porous HA/BaTiO3 ceramics have the potential to exhibit superior capabilities to promote bone in-growth.However,there are few reports on in vivo studies.Here,we fabricated bio-inspired porous HA/BaTiO3 composites for bone repair via freeze-casting.These composites had a unique microstructure composed of the central canal and radically distributed lamellae,similar to the structure of nature cortical bone unite,the Haversian system.Polarized and non-polarized bio-in-spired porous HA/BaTiO3 samples were implanted into the femoral condyle of the New Zealand rabbits.It was demonstrated that the polarization of the porous HA/BaTiO3 played a favorable part in bone regeneration.Moreover,the combination between the osteoconductivity of the microstructure and augmented osteogenic cell behavior induced by charges on surfaces of polarized porous HA/BaTiO3 facilitated bone penetration through the implants.The bio-inspired porous HA/BaTiO3 composites are demonstrated to be promising scaffolds for bone repair.
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