肽抗生素是由生物体基因编码的肽类物质 ,广泛存在于自然界中 ,是生物体非特异性免疫的重要组成部分 ,具有抗菌活性强、抗菌谱广、不易产生耐药性等优点。在未来抗感染治疗中有广阔的应用前景。肽抗生素的制备是制约其开发应用的关键环节。作者对肽抗生素工程制备的有关进展进行综述 ,包括酵母、杆状病毒、大肠杆菌等表达技术在肽抗生素制备中的应用 ,以及转基因动、植物在制备肽抗生素中的巨大潜力 Peptide antibiotics are encoded by biological genes of the peptide, widely exist in nature, is an important part of non-specific immune organisms, with antibacterial activity, broad antibacterial spectrum, not easy to produce resistance and so on. In the future anti-infective treatment has broad application prospects. Preparation of peptide antibiotics is to restrict the development and application of key links. The authors reviewed the progress of peptide antibiotic engineering, including the application of yeast, baculovirus and E.coli in the preparation of peptide antibiotics, as well as the great potential of transgenic animals and plants in the preparation of peptide antibiotics