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青霉素过敏性休克的机制是个长期未解决的问题,近年来国内外研究认为青霉素杂质是引起过敏反应的过敏原。有的认为青霉噻唑基团是主要决定簇,有的认为青霉噻唑蛋白以外某些杂质(次要决定簇)和青霉素过敏性休克发生有密切关系。但究竟哪种杂质和过敏性休克发生有直接关系?尚在争论。为了研究青霉噻唑蛋白和发生过敏性休克的关系,我们进行了如下实验:(1)青霉噻唑蛋白致敏豚鼠过敏休克模型的观察,发现用青霉素 G 和青霉噻唑蛋白攻击后,
The mechanism of penicillin anaphylactic shock is a long-term unsolved problem, in recent years, domestic and foreign studies believe that penicillin impurities cause allergic reactions allergens. Some believe that the penicillium thiazole group is the main determinant, and some think that some impurities other than penicillin thiazole protein (secondary determinants) and penicillin anaphylactic shock are closely related. But what kind of impurities and the occurrence of anaphylactic shock have a direct relationship? Still debating. In order to study the relationship between penicillin and anaphylactic shock, we conducted the following experiments: (1) Observation of allergic shock model induced by penicillin in guinea pigs, we found that after the challenge with penicillin G and penicillin,