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神经胶质瘤的高侵袭性是导致临床化疗效果欠佳的最主要原因。胶质瘤细胞向正常组织的侵润在限制化疗药物疗效发挥的同时也增加了外科手术的复杂性。基于以上背景本次研究提出降低肿瘤细胞的侵袭性可以增加化疗效果的设想。体外研究发现丙咪嗪蓝可以通过抑制肿瘤细胞中NADPH氧化酶介导的氧自由基产生并调节肌动蛋白的表达来降低侵袭性。作者使用一种具有人脑肿瘤关键性特征的侵袭型胶质瘤大鼠作为动物模型,使用丙咪嗪蓝脂质体后,大鼠的肿瘤组织更为密实。以丙咪嗪脂质体结合阿霉素治疗作为实验组,单独使用阿霉素治疗作为对照组,结果发现实验组大鼠存活时间均超过180天,其有效比例明显高于对照组(33%)。本次研究的结果对于结合丙咪嗪与阿霉素治疗神经胶质瘤的治疗模式探讨提供了极其重要的理论支持。
The high aggressiveness of glioma is the leading cause of poor clinical chemotherapy. Invasion of glioma cells into normal tissues also increases the complexity of the surgical procedure while limiting the efficacy of chemotherapeutic drugs. Based on the above background this study proposed to reduce the aggressiveness of tumor cells can increase the effect of chemotherapy. In vitro studies showed that imipramine blue can reduce invasiveness by inhibiting NADPH oxidase mediated oxygen free radical production in tumor cells and regulating actin expression. The authors used an invasive glioma rat, a key feature of human brain tumors, as an animal model. After using imipramine blue liposomes, the tumor tissue in rats was denser. Imipramine liposomes combined with doxorubicin treatment as experimental group, alone doxorubicin treatment as a control group, the experimental group rats were found to survive for more than 180 days, the effective proportion was significantly higher than the control group (33% ). The results of this study provide an extremely important theoretical support for the treatment of glioma with imipramine combined with imipramine.