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[目的]研制出各项性能指标合格的50%醚菌酯水分散粒剂。[方法]以制剂悬浮率和崩解性为考察指标,对分散剂、润湿剂、崩解剂及填料进行筛选。[结果]50%醚菌酯水分散粒剂最佳配方(以质量分数计):有效成分质量分数为96%的醚菌酯52%,分散剂GY-D800 6%、助分散剂GY-SN02 10%、润湿剂GY-WS01 3%、崩解剂氯化钠10%、填料为高岭土18%、黏结剂为水。[结论]对制剂性能指标检测,结果表明该产品的崩解分散性好,热贮前悬浮率为91.0%,6次崩解,持久泡沫量为0,热贮(54±2)℃,14 d后悬浮率为83.3%,5次崩解,持久起泡性量为0,有效成分热贮分解率3.2%,各项指标均符合国标要求。
[Objective] The research aimed to develop the 50% ketoconazole ester water dispersible granules with various performance indexes. [Method] With the suspending rate and disintegratability as the index, the dispersant, wetting agent, disintegrant and filler were screened. [Result] The optimum formulation of 50% ketoxystrobin water dispersible granules (in mass fraction): 52% of kresoxim-methyl with 96% active ingredient, 6% dispersant GY-D800 and dispersant GY-SN02 10%, wetting agent GY-WS01 3%, disintegrating agent sodium chloride 10%, filler 18% kaolin, binder water. [Conclusion] The performance index of the preparation was tested. The results showed that the product had good disintegration and dispersibility, the pre-storage suspension rate was 91.0%, the disintegration was 6 times, the lasting foam volume was 0, the storage temperature was 54 ± 2 ℃, 14 d after the suspension rate of 83.3%, 5 times disintegration, the amount of persistent foaming 0, the effective ingredient thermal storage decomposition rate of 3.2%, all indicators are in line with national standards.