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合成本品由异黄樟脑(1)经溴化、水解反应,所得物(11)与吗啉(111)缩合而得[BE893174;CA 1160631;JP 79-27882;US374593]。药理作用小白鼠苯醌试验表明,口服本品ED_(50)为70mg/kg,治疗指数为17.1,优于阿司匹林和氨基比林。热板试验中,本品的作用高于阿司匹林10倍,较氨基比林强1.4倍,是可待因的0.5倍,口服的ED_(50)为155mg/kg。经小白鼠热辐射试验表明,其止痛作用介于可待因和氨基比林之间;对大白鼠的抓压试验表明,对常力抓和剧力抓均有效,并可分为抗剧痛和麻醉两种效果;对角叉
Synthesis of the goods from isoflavones (1) by bromination, hydrolysis reaction, the resulting product (11) and morpholine (111) condensation [BE893174; CA 1160631; JP 79-27882; US374593]. Pharmacological effects of mice benzoquinone test showed that oral ED50 (50) of 70mg / kg, the therapeutic index of 17.1, better than aspirin and aminopyrine. In the hot plate test, the effect of this product is 10 times higher than that of aspirin, 1.4 times stronger than aminopyrine, 0.5 times that of codeine, and the oral ED 50 is 155 mg / kg. The mice heat radiation test showed that its analgesic effect was between codeine and aminopyrine; the rat’s pressure test showed that the grasp of the force and the grasping force are effective, and can be divided into anti-severe pain And anesthesia two effects; diagonal fork