痛风的罪魁祸首为嘌呤及尿酸代谢障碍,表现为高尿酸血症、反复发作的急性关节炎、痛风石和痛风石引起的慢性关节炎。而长期高尿酸血症导致的肾脏损害远远没有引起痛风患者的重视,因此导致的尿毒症正在逐年增加。痛风肾损害主要表现为痛风性肾病、急慢性肾功能衰竭和尿路结石。其发生主要是由于尿酸盐结晶在肾脏沉积,并引起炎症反应,或尿酸结晶沉积引起尿路阻塞。痛风性肾病的临床表现可有尿酸结石、小分子蛋白尿、水肿、夜尿、高血压、 The culprit gout for the purine and uric acid metabolism disorders, manifested as hyperuricemia, recurrent acute arthritis, tophi and tophi caused by chronic arthritis. Long-term hyperuricemia caused by kidney damage is far from gout patients, so the resulting uremia is increasing year by year. Gout kidney damage mainly for gouty kidney disease, acute and chronic renal failure and urinary tract stones. Its occurrence is mainly due to the accumulation of urate crystals in the kidneys, and cause inflammatory reactions, or deposition of uric acid crystals cause urinary tract obstruction. Gout nephropathy may have clinical manifestations of uric acid stones, small proteinuria, edema, nocturia, hypertension,