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总结15例肾移植术后患者应用骁悉(MMF)预防急性排斥反应的效果。发现MMF与环孢素A(CsA)和强的松联合应用能有效地预防急性排斥反应的发生,特别是肾移植术后移植肾功能延迟恢复、骨髓抑制和(或)肝功能异常的患者;降低CsA的常规用量同样能够有效地预防排斥反应的发生,同时降低了CsA对肝脏、肾脏和骨髓的毒性。认为MMF是一种新型、强力免疫抑制剂,能够有效地预防排斥反应的发生,减少常见免疫抑制药物毒副作用的发生。
The effect of MMF on acute rejection in 15 patients after renal transplantation was summarized. Found that combined use of MMF and cyclosporin A (CsA) and prednisone can effectively prevent the occurrence of acute rejection, especially in patients with delayed renal transplantation, bone marrow suppression and / or abnormal liver function after renal transplantation; Lowering the conventional dose of CsA can also effectively prevent the occurrence of rejection while reducing the toxicity of CsA to liver, kidney and bone marrow. It is considered that MMF is a new type of potent immunosuppressant that can effectively prevent rejection and reduce the side effects of common immunosuppressive drugs.