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目的 探讨微血管形成在非小细胞肺癌中的表达及其临床意义。方法 采用免疫组织化学的方法 ,对33例病人非小细胞肺癌进行分析。结果 全部 33例非小细胞肺癌中 ,淋巴结转移组 :微血管密度 (MVD)为 43 6± 2 2 3,非淋巴结转移组 :为 2 4 6± 17 3(P <0 .0 1)。生存期 >5年 ,MVD为 2 2 4± 16 8,生存期 <半年者为 5 8 6± 2 3 4,P <0 0 1。结论MVD对非小细胞肺癌的转移及预后有预测作用 ,它的检测可为临床诊治提供更多依据。
Objective To investigate the expression of microvessel formation in non-small cell lung cancer and its clinical significance. Methods 33 cases of non-small cell lung cancer were analyzed by immunohistochemistry. Results Of all 33 NSCLC patients, the lymph node metastasis group had a microvessel density (MVD) of 43 6±2 2 3 and a non-lymph node metastasis group of 2 4 6± 17 3 (P < 0.01). The survival period was >5 years, the MVD was 2 2 4±16 8, and the survival period was < 5 8 6 ± 2 3 4, and P <0 0 1. Conclusion MVD can predict the metastasis and prognosis of non-small cell lung cancer. Its detection can provide more basis for clinical diagnosis and treatment.