内源性类洋地黄物质(endogenous digoxinike substances,EDLS)是体内产生和分泌的一种具有洋地黄活性的生物活性物质,能抑制Na-K-ATPase,特异地与喹巴因受体结合,与地高辛抗体产生交叉结合反应,故可用放射免疫方法进行检测。该物质产生于下丘脑,高钠摄入和血容量扩张能刺激其释放。EDLS的化学本质尚不清楚,它具有利钠、强心、收缩血管的作用,有报道在慢性肝病、肾病及高血压时可出现血浆EDLS水平升高。糖尿病(DM) Endogenous digoxigenin (EDLS) is a digitalis-producing, bioactive substance that is produced and secreted in vivo and inhibits the binding of Na-K-ATPase to quinabain receptors, specifically Digoxin antibody cross-binding reaction, it can be detected by radioimmunoassay. The substance is produced in the hypothalamus, and high sodium intake and blood volume expansion can stimulate its release. The chemical nature of EDLS is not yet clear, it has sodium, cardiac, systolic blood vessels, it has been reported in the chronic liver disease, kidney disease and hypertension can occur when the plasma EDLS levels. Diabetes (DM)