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目的 观测内毒素血症时家兔脑组织血流总量及其分配的改变 ,并探讨这种变化的发生机理。方法 静脉注射内毒素造成动物内毒素血症 ,用放射性生物微球法检测注射中和性抗rhTNF单克隆抗体前后脑组织血流量的变化。结果 (1)内毒素组的左右半侧脑组织平均血流量及脑干、脑桥血流量均显著低于对照组 (P <0 0 1) ;(2 )无关抗体组的左右半侧脑组织平均血流量及脑干、脑桥血流量均显著低于抗体保护组 (P <0 0 1)。结论 严重内毒素血症可致脑血流量减少及脑组织内部血流分配紊乱 ,而抗rhTNF单克隆抗体可予以有效纠正。
Objective To observe the changes of total blood flow and distribution of brain tissue in rabbits with endotoxemia and to explore the mechanism of this change. Methods Endotoxin was injected intravenously to cause endotoxemia in animals. The changes of blood flow in brain tissue before and after injection of neutralizing rhTNF monoclonal antibody were detected by radioactive microspheres method. Results (1) The mean blood flow and the brainstem and pontine blood flow in left and right hemisphere of endotoxin group were significantly lower than those in control group (P <0.01). (2) Blood flow, brain stem and pontine blood flow were significantly lower than the antibody protection group (P <0.01). Conclusions Serious endotoxemia can result in the decrease of cerebral blood flow and disorder of blood flow distribution in brain tissue, while the anti-rhTNF monoclonal antibody can be effectively corrected.