目的研究不同配比的大黄和姜黄组方,比较其降脂效果的差异,为临床合理应用大黄与姜黄的组方治疗高脂血症奠定基础。方法给大鼠灌服高脂乳剂,建立高血脂症模型,随机分4组,即对照组,大黄与姜黄比例为1:1组,1:2组,2:1组,造模的同时对实验组的大鼠给药,干预高血脂症的形成。4周后,测定血浆中总胆固醇(CHO),甘油三酯(TG),高密度脂蛋白(HDL-C),低密度脂蛋白(LDL-C)的浓度,将数据进行统计分析,观察各组差异。结果各实验组与对照组差异均有统计学意义,2:1组与1:1组及1:2组的HDL-C、LDL-C、CHO差异存在统计学意义,其他几组的各指标均未见统计学差异。结论大黄与姜黄比为2:1的组方配比降高血脂疗效优于其他实验组。 Objective To study the different prescriptions of rhubarb and curcumin and to compare their differences in their lipid-lowering effects, so as to lay a foundation for the clinical rational use of rhubarb and turmeric in the treatment of hyperlipidemia. Methods The rats were fed with high-fat emulsion and hyperlipidemia model was established. The rats were randomly divided into 4 groups, namely control group, rhubarb and turmeric ratio of 1: 1, 1: 2 and 2: Rats in the experimental group were given drugs to interfere with the formation of hyperlipidemia. Four weeks later, the concentrations of total cholesterol (CHO), triglyceride (TG), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) in plasma were measured, and the data were statistically analyzed. Group differences. Results There were significant differences between the experimental group and the control group, HDL-C, LDL-C, CHO of 2: 1 group and 1: 1 group and 1: 2 group were statistically significant differences in the other groups of indicators No statistical difference was found. Conclusion The combination of rhubarb and turmeric ratio 2: 1 decreased the blood lipid effect than other experimental groups.