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目的:探究左氧氟沙星联合化疗治疗复治涂阳肺结核(TB)的临床疗效及其对患者外周血T细胞亚群水平的影响。方法:自2013年03月~2016年03月我院收治TB病例中选择88例为观察对象,并随机等分为对照组(44例)、观察组(44例),均给予常规化疗,观察组此基础上给予左氧氟沙星。对比两组患者疗效和外周血T细胞亚群水平。结果:观察组临床有效率(93.18%)高于对照组(77.27%),差异显著(P<0.05);观察组CD3+为(1434.40±138.31)、CD4+为(689.21±99.29)、CD8+(499.31±45.49)均高于对照组(1000.88±132.81,577.41±90.25,398.32±45.53),差异均显著(P<0.01)。结论:在化疗基础上给予TB患者左氧氟沙星,可改病人外周血内T细胞亚群实际水平,获得更好疗效,因此值得应用。
Objective: To investigate the clinical efficacy of levofloxacin combined with chemotherapy in the treatment of relapsed smear-positive pulmonary tuberculosis (TB) and its effect on the level of T lymphocyte subsets in peripheral blood of patients. Methods: From March 2013 to March 2016, 88 cases of TB patients treated in our hospital were selected and randomly divided into control group (44 cases) and observation group (44 cases). All patients were given conventional chemotherapy and observed Group this on the basis of levofloxacin. Efficacy and peripheral blood T cell subsets levels were compared between the two groups. Results: The clinical effective rate (93.18%) in the observation group was significantly higher than that in the control group (77.27%) (P <0.05). The CD3 + in the observation group was (1434.40 ± 138.31), CD4 + was (689.21 ± 99.29) 45.49) were higher than the control group (1000.88 ± 132.81,577.41 ± 90.25,398.32 ± 45.53), the difference was significant (P <0.01). CONCLUSION: Levofloxacin given to patients with TB on the basis of chemotherapy can change the actual level of T cell subsets in patients’ peripheral blood and obtain better curative effect, so it is worth to be applied.