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锂是人体健康非必需的痕量元素。在临床医学上已成功用碳酸锂于精神病患者的治疗,但锂盐有毒性,过量摄入有昏睡致死的危险。近年已有测定血清锂的报导。由于火焰原子吸收灵敏度不高,不能测定血清中ppb级的锂。高温石墨炉技术灵敏度很高,已用于岩石、金属铀和血清锂的测定。据发现CaCl_2有气相干扰,且Na/Li大于3×10~4倍时,由于钠盐的分子吸收明显而不能正确测定锂。本报告用(NH_4)_2SO_4作基体改良剂,克服了CaCl,降低了NaCl的影响,并以锆的原子线670.2nm作邻近非共振线,对锂的原子吸收线670.78nm进行背景扣除,从而克服了上述困难。经适当稀释即可直接测定血清中ppb级的锂,此方法的精密度与回收率均为良好。
Lithium is a non-essential trace element of human health. In clinical medicine lithium carbonate has been successfully used in the treatment of patients with mental illness, but the lithium salt toxicity, excessive intake of lethargy risk of lethargy. In recent years, there have been reports of serum lithium. Due to the flame atomic absorption sensitivity is not high, can not measure ppb level of serum lithium. High-temperature graphite furnace technology is highly sensitive, has been used for rock, uranium and serum lithium determination. It was found that there is gas phase interference of CaCl_2, and when Na / Li is more than 3 × 10 ~ 4 times, lithium can not be measured correctly due to the obvious molecular absorption of sodium salt. This report overcomes the effect of NaCl by using (NH 4) 2 SO 4 as a matrix modifier, and overcomes the influence of NaCl by using the adjacent non-resonant line of zirconium atomic line 670.2 nm to background subtract the atomic absorption line 670.78 nm of lithium, thereby overcoming The above difficulties. Proper dilution can be directly measured in serum ppb level of lithium, the precision and recovery of this method are good.