新生儿与成人在生理条件上的差别很大。例如新生儿细胞外液容积大,肝肾功能不健全,血浆中内源物质(如胆红素)较高等。这些差别影响着药物的体内分布、代谢和排泄、因此很难建立起新生儿最佳给药方案。在新生儿各种感染疾病的治疗中,β-内酰胺类抗生素应用最广泛。因此了解和预测这类药物的体内分布容积,对新生儿的抗生素治疗是非常重要的。本文对11名新生儿进行了头孢唑啉治疗的研究。选用头孢唑啉作为β-内酰胺类抗生 Newborn and adult differences in physiological conditions vary greatly. For example, neonatal extracellular fluid volume, liver and kidney dysfunction, plasma endogenous substances (such as bilirubin) higher. These differences affect the drug’s in vivo distribution, metabolism and excretion, so it is difficult to establish the best neonatal dosing regimen. In neonatal treatment of various infectious diseases, β-lactam antibiotics are the most widely used. Therefore, to understand and predict the distribution volume of these drugs in vivo is very important for neonatal antibiotic treatment. In this paper, 11 newborns were treated with cefazolin. Cefazolin selected as β-lactam antibiotics