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目的探讨补充微量营养素对不同空腹血糖水平的2型糖尿病(T2DM)男性患者感染的影响。方法73例T2DM男性患者随机分为安慰剂组(36例)和干预组(37例),分别补充安慰剂和微量营养素制剂,连续服用6个月。在研究开始前和结束时进行人体测量和血液及免疫指标检测。研究前1个月及研究期间每月随访1次,每2周记录1次饮食、运动情况,每月进行一次感染情况登记。结果安慰剂组血糖≤6.1mmol/L者10例,血糖>6.1mmol/L者24例;干预组血糖≤6.1mmol/L者15例,血糖>6.1mmol/L者21例。6个月后,与安慰剂组血糖≤6.1mmol/L者相比,干预组血糖≤6.1mmol/L者叶酸含量明显增加,发热持续时间缩短,感冒、化脓性指头炎、阴道炎或尿路感染、牙龈炎和口腔溃疡发生率均降低(P<0.05)。与安慰剂组血糖>6.1mmol/L者相比,干预组血糖>6.1mmol/L者叶酸、CD8+、CD4+/CD8+、糖化血红蛋白、不饱和铁结合力的变化值均较高(P<0.05),而感冒、肾盂肾炎或膀胱炎、阴道炎或尿路感染、牙龈炎和口腔溃疡发生率显著降低(P<0.05)。结论无论空腹血糖控制如何,补充微量营养素均可降低T2DM男性患者一般感染的发生率。
Objective To investigate the effect of micronutrient supplementation on the infection of male patients with type 2 diabetes mellitus (T2DM) with different fasting blood glucose levels. Methods Seventy-three male patients with T2DM were randomly divided into placebo group (n = 36) and intervention group (n = 37). Placebo and micronutrient preparations were given separately for 6 months. Body measurements and blood and immune indices were taken before and at the end of the study. One month before the study and the monthly follow-up during the study 1, every 2 weeks record 1 diet, exercise, monthly infection registration. Results In the placebo group, 10 patients with blood glucose ≤6.1mmol / L and 24 patients with blood glucose> 6.1mmol / L, and 15 patients with blood glucose ≤6.1mmol / L and 21 patients with blood glucose> 6.1mmol / L in the intervention group. After 6 months, compared with the placebo group, blood glucose <6.1mmol / L, the intervention group, blood glucose <6.1mmol / L significantly increased the content of folic acid, shorter duration of fever, cold, purulent finger inflammation, vaginitis or urinary tract Infection, gingivitis and the incidence of oral ulcers were reduced (P <0.05). Compared with the placebo group, blood glucose> 6.1 mmol / L, the changes of the binding capacity of folate, CD8 +, CD4 + / CD8 +, HbA1c, , Whereas the incidence of colds, pyelonephritis or cystitis, vaginitis or urinary tract infection, gingivitis and oral ulcer were significantly reduced (P <0.05). Conclusion Regardless of fasting glucose control, micronutrient supplementation can reduce the incidence of T2DM in men.