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探讨急性脑梗死血清及脑脊液 (C .S .F)血管内皮细胞生长因子 (VEGF)的动态变化及临床意义。方法 :采用ELISA双抗夹心法 ,测定 32例急性脑梗死患者 48h内、7d、14d血清VEGF及 48h内、7dC .S .FVEGF的含量。结果 :急性脑梗死后各个时期 ,血清VEGF均高于健康对照组 (P <0 .0 1) ,且以 7d时更明显 ,与 48h比较P <0 .0 5 ,与 14d比较P <0 .0 1;48h内和 7d两组间C .S .FVEGF无明显变化 (P >0 .0 5 )。脑梗死面积 >2 0ml组在各个时期的血清VEGF水平均高于 10～ 2 0ml组和 <10ml组 (P <0 .0 5 ) ,而 10～ 2 0ml组与 <10ml组间血清VEGF无差异 (P >0 .0 5 )。结论 :VEGF参与了急性脑梗死的血管重建 ,有利于脑梗死缺血半暗区血供的早期恢复 ,VEGF的升高与梗死面积的大小呈正相关。 <2 0ml的脑梗死患者VEGF升高愈明显预后愈好。为今后VEGF的基因治疗提供了理论依据。
To investigate the dynamic changes of vascular endothelial growth factor (VEGF) in serum and cerebrospinal fluid (CSF) of patients with acute cerebral infarction and its clinical significance. Methods: The serum levels of VEGF, 7d, 14d and 7dc, sfgf were detected in 48 patients with acute cerebral infarction within 48h, 7d, 14d by ELISA double antibody sandwich method. Results: The levels of serum VEGF in all stages of acute cerebral infarction were significantly higher than those in healthy controls (P <0.01), and were more obvious at 7 days, P <0. 05 compared with 48 hours, P <0. There was no significant change of C · S · FVEGF between 0 1, 48 h and 7 d (P> 0.05). The levels of serum VEGF in cerebral infarction area> 20ml group were higher than those in 10 ~ 20ml group and <10ml group (P <0.05), while there was no difference in serum VEGF between 10 ~ 20ml group and <10ml group (P> 0.05). Conclusion: VEGF is involved in the revascularization of acute cerebral infarction, which is propitious to the early recovery of blood supply in the penumbra of ischemic cerebral infarction. The increase of VEGF is positively correlated with the infarct size. <200ml of cerebral infarction in patients with elevated VEGF more obvious prognosis the better. It provides a theoretical basis for the gene therapy of VEGF in the future.