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严重再生障碍性贫血(SAA)发病机制中干细胞失去其增殖分化的机理仍未完全阐明,除干细胞缺陷外,淋巴细胞与干细胞相互作用和/或细胞因子网络系统调节障碍可能与造血衰竭有关。本文报告1例 SAA 静脉与皮下注射 RhIL-3治疗时血液学反应及治疗前后定期测细胞因子变化。病人为37岁女性,1978年确诊为 SAA,抗淋巴
The mechanisms by which stem cells lose their proliferation and differentiation in the pathogenesis of severe aplastic anemia (SAA) have not been fully elucidated. In addition to stem cell defects, lymphocyte-stem cell interactions and / or regulatory disorders of the cytokine network may be associated with hematopoietic failure. This article reports the hematologic response of one case of SAA vein and subcutaneous RhIL-3 and the regular changes of cytokines before and after treatment. The patient was a 37-year-old woman and was diagnosed as SAA in 1978 against lymph nodes