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目的:制备儿茶凝胶,并对凝胶的释放行为和抗炎药效学进行研究。方法:以儿茶素和表儿茶素的含量总和占儿茶质量的百分比为提取率作为考察指标,采用正交试验,考察乙醇浓度、料液比、提取温度和超声时间4个因素对提取结果的影响,儿茶提取物以卡泊姆为基质,三乙醇胺为中和剂制成儿茶凝胶,对凝胶的体外释药性和大鼠抗炎药效进行研究。结果:超声波醇提法提取儿茶的优化工艺条件为乙醇浓度为50%,料液比为1∶12,超声时间为35 min,提取温度为60℃。儿茶凝胶处方卡波姆9 400.5 g,甘油5.0 g,儿茶提取物50.0 mL,三乙醇胺0.5 mL,儿茶凝胶细腻光洁、呈半透明;释放药物快;对角叉菜胶所致的大鼠足趾肿胀具有明显的抑制作用,作用时间与凝胶剂量呈正性相关。结论:儿茶凝胶配方合理,质量可控,具有明显的抗炎作用,可进一步研究开发。
OBJECTIVE: To prepare catechu gel and study its release behavior and anti-inflammatory pharmacodynamics. Methods: Taking the percentage of catechin and epicatechin as the percentage of catechu as extraction index, orthogonal test was used to study the effects of ethanol concentration, solid-liquid ratio, extraction temperature and ultrasonic time on extraction The results showed that the catechu extract was made from carbomer and triethanolamine as the neutralizer to make catechu gel. The in vitro release of the gel and the anti-inflammatory effect of the rat were studied. Results: The optimum extraction conditions for extraction of catechu by ultrasonic alcohol extraction were that ethanol concentration was 50%, solid-liquid ratio was 1:12, ultrasonic time was 35 min, extraction temperature was 60 ℃. Coca-Cola gel prescription 400 400 g, glycerol 5.0 g, Catechu extract 50.0 mL, Triethanolamine 0.5 mL, Catechu gel fine and smooth, translucent; Drug release fast; Caused by carrageenan Of rat toe swelling has a significant inhibitory effect, the role of time and gel dose was positively correlated. Conclusion: Catechu gel formula is reasonable, quality control, with significant anti-inflammatory effect, further research and development.