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目的探讨乙型肝炎病毒(HBV)活动对血管侵袭发展的潜在影响,力求提供新的有效的治疗方案。方法 2015年5月1日~2017年4月31日,选取确定120例术前诊断为肝癌手术切除手术的患者,回顾性分析HBV患者和肝切除术后肝癌患者肿瘤相关因素,分析其发生血管入侵的危险因素。结果单变量分析显示,乙肝病毒表面抗原(HBs Ag)阳性与血管入侵明显相关。在HBV相关肝细胞癌(HCC)患者进行的多变量回归分析中,乙型肝炎E抗原(HBe Ag)(OR=1.83,P=0.019)与可检测的血清HBV DNA载量(OR=1.68,P=0.027)是导致肿瘤血管侵犯的独立危险因素。结论在HCC患者中,HBV感染和HBV复制活动与血管侵犯的发生有关。
Objective To investigate the potential impact of hepatitis B virus (HBV) activity on the development of vascular invasion and seek new and effective treatment options. Methods From May 1, 2015 to April 31, 2017, 120 patients with preoperative diagnosis of liver cancer undergoing surgical resection were selected. The related factors of tumor in patients with hepatocellular carcinoma after liver resection and retrospective analysis were analyzed retrospectively. Invasion risk factors. Results Univariate analysis showed that the positive of HBs Ag was significantly associated with vascular invasion. In multivariable regression analysis of patients with HBV-associated hepatocellular carcinoma (HCC), HBeAg (OR = 1.83, P = 0.019) and detectable serum HBV DNA load P = 0.027) is an independent risk factor for tumor vascular invasion. Conclusions In HCC patients, HBV infection and HBV replication activities are associated with the occurrence of vascular invasion.