,Periostin: a potent chemotactic factor for recruiting tumor-associated macrophage

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Glioblastoma (GBM) is the most common malignant primary brain tumor with a low five-year survival rate.Evidence from experimental and clinical studies indicates that glioma stem cells (GSCs) contribute to GBM tumor growth,therapeutic resistance and relapse (Bao et al.,2006;Gilbertson and Rich,2007).
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