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目的观察米索前列醇联合缩宫素预防产后出血的疗效。方法选择足月妊娠产妇260例,随机分为对照组和观察组各130例,两组产妇均于胎儿娩出后立即给药,对照组给予缩宫素治疗,观察组在对照组基础上加用米索前列醇200μg舌下含服,比较两组临床疗效。结果观察组第三产程时间短于对照组,产后2h及24h出血量少于对照组,两组比较差异均有统计学意义(P<0.05);药物不良反应及新生儿阿氏评分两组间差异无统计学意义(P>0.05)。结论米索前列醇联合缩宫素可有效减少产后出血量,优于单用缩宫素组,值得临床推广应用。
Objective To observe the effect of misoprostol combined with oxytocin in preventing postpartum hemorrhage. Methods 260 pregnant women of full-term pregnancy were randomly divided into control group and observation group of 130 cases, both groups of maternal were given immediately after the delivery of the fetus, the control group was treated with oxytocin, the observation group on the basis of the control group Misoprostol 200μg sublingual administration, the clinical efficacy of two groups were compared. Results The duration of the third stage of labor in the observation group was shorter than that in the control group. The amount of bleeding at 2h and 24h postpartum was less than that in the control group, with significant differences between the two groups (P <0.05). Adverse drug reactions and neonatal Asperger’s score The difference was not statistically significant (P> 0.05). Conclusion Misoprostol combined with oxytocin can effectively reduce the amount of postpartum hemorrhage, which is superior to single oxytocin group, which is worthy of clinical application.