论文部分内容阅读
目的 分析多囊肾病 (PKD)患者肾移植术后移植效果 ,并探讨影响因素。方法 选取19 78年至 2 0 0 2年 46例PKD肾移植患者 (PKD组 )和 46例其它肾脏病 (非糖尿病肾病 )肾移植患者(对照组 )进行回顾性分析。评估人、肾存活率 (肾移植后 1、3和 5年 ) ,以及术后并发症 ,如感染和心血管疾病等情况。结果 两组患者 1、3、5年人存活率 :PKD组为 95.7%、91.3 %、91.3 % ;对照组为97.8%、95.7%、93 .5% ;肾存活率 :PKD组为 93 .5%、89.1%、87.0 % ;对照组为 95.7%、89.1%、87.0 %。PKD组中 ,女性患者 5年移植人、肾存活率达到 10 0 %、10 0 % ,男性只有 88.2 %、82 .4% ,差异有显著性 (P <0 .0 5)。PKD组患者比对照组更易发生尿路感染 (P <0 .0 5) ;其它部位的感染发生率相似。两组心血管并发症差异无显著性 (PKD组 3例 ,对照组 4例 )。结论 PKD组和对照组总的人、肾存活率差异无显著性。PKD组的女性患者肾移植后存活率高于男性 ,可能与性激素的影响有关。尿路感染和严重的肺部感染可能是PKD患者术后主要的并发症。
Objective To analyze the effect of renal transplantation in patients with polycystic kidney disease (PKD) and to explore the influencing factors. Methods 46 cases of PKD patients (PKD group) and 46 cases of other kidney disease (non-diabetic nephropathy) renal transplant recipients (control group) were retrospectively analyzed from 1978 to 2002. Renal and renal survival rates (1, 3, and 5 years after renal transplantation) were assessed, as were postoperative complications such as infection and cardiovascular disease. Results The survival rates at 1, 3 and 5 years in both groups were 95.7%, 91.3% and 91.3% in the PKD group and 97.8%, 95.7% and 93.5% in the control group, respectively. The survival rate of the kidney in the PKD group was 93.5% %, 89.1%, 87.0%; control group was 95.7%, 89.1%, 87.0%. In the PKD group, the 5-year female patient’s graft survival rate was 100% and 100% respectively, with only 88.2% and 82.4% in men (P <0.05). Patients in the PKD group were more likely to develop urinary tract infections than those in the control group (P <0. 05). The incidence of infection in other sites was similar. There were no significant differences in cardiovascular complications between the two groups (3 in PKD group and 4 in control group). Conclusion There was no significant difference in the overall survival rate of kidney between the PKD group and the control group. The survival rate of female patients in PKD group after kidney transplantation was higher than that in male, which may be related to the effect of sex hormones. Urinary tract infections and severe lung infections may be the major postoperative complications of PKD.