新生隐球菌脑膜炎为一种深部霉菌感染性疾病,常合并肺、肾、皮肤、骨骼等其它病变。本病进展缓慢,常与某些中枢神经系统疾病相混淆,易造成误诊而延误治疗,往往导致严重的后果。过去,本病的治疗较为困难,死亡率甚高。虽然在二性霉素乙问世以后疗效有所改观,但是由于二性霉素乙毒性较大,病人往往在治疗过程中出现严重的毒性反应,不得不中 Cryptococcus neoformans meningitis is a deep fungal infection of the disease, often associated with lung, kidney, skin, bone and other lesions. The slow progress of the disease, often associated with certain central nervous system diseases, easily lead to misdiagnosis and delay treatment, often leading to serious consequences. In the past, the treatment of this disease is more difficult, the mortality rate is very high. Although the efficacy of amphotericin B has changed somewhat since the advent of amphotericin B, patients have often experienced severe toxic reactions during treatment due to the toxicity of amphotericin B