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目的:探讨不同时间口服阿司匹林所致的消化道损伤。方法:以我院2008年7月1日-2012年6月30日,口服阿司匹林进行心脑血管病的一级、二级预防的门诊或住院患者2386人作为研究对象,随机分为晨间空腹口服组(晨服组1204人)和晚间睡前口服组(晚服组1180人),并记录核实患者提供的基本信息,以及口服阿司匹林后出现的消化道不良反应状况。结果:晨服组254例出现消化道不良反应,占21.1%,其中消化道出血33例,占2.74%;晚服组405例出现消化道不良反应,占34.26%,其中消化道出血86例,占7.36%;两组具有显著差异性(P<0.05)。结论:晨间口服阿司匹林可明显降低少消化道不良反应的发生率;尤其显著降低消化道出血的发生率。
Objective: To investigate the different times of oral administration of aspirin-induced gastrointestinal injury. Methods: From July 1, 2008 to June 30, 2012, 2,386 outpatients or inpatients with primary and secondary prevention of cardiovascular and cerebrovascular diseases from oral administration of aspirin were randomly divided into morning fasting The oral group (1204 morning service group) and nighttime bedtime oral group (1180 night service group), and record the verification of the basic information provided by the patients, as well as oral gastrointestinal adverse reactions occurred after aspirin. Results: In the morning service group, 254 cases showed adverse reactions of gastrointestinal tract, accounting for 21.1%, including 33 cases of gastrointestinal bleeding, accounting for 2.74%. In the evening service group, 405 cases had gastrointestinal adverse reactions (34.26%), including 86 cases of gastrointestinal bleeding, Accounting for 7.36%. There was significant difference between the two groups (P <0.05). Conclusion: Morning oral aspirin can significantly reduce the incidence of adverse reactions of gastrointestinal tract; especially significantly reduce the incidence of gastrointestinal bleeding.