[Objective]To investigate the antifungal effect of essential oils from 5 medicinal herbs on Candida albicans.[Method]By adopting tube disk approach,the essential oils of cinnamon bark,palchouli,clove,fennel and Schisandra rosea were respectively diluted to 2.5-0.019 5 μL/mL by tiraes ratio dilution for MIC and MFC experiments on pathogenic Candida albicans strains (Monilia albican,Candida tropical,Candida krusei) from intestinal tract,lung and kidney.[Results]The MIC and MFC of cinnamon bark oil against Candida albicans were 0.039 and 0.078 μL/mL respectively; those of clove oil against Candida albicans were 0.156 and 0.312 5 μL/mL respectively; those of palchouli oil against Candida albicans were 0.313 and 0.625 μL/mL respectively; those of fennel oil oil against Candida albicans were 0.156 and 0.312 5 μL/mL respectively.The MIC of Schisandra rosea oil against Candida albicans (Monilia albican,Candida krusei) was 0.312 5 μL/mL,that against Candida tropical was 0.625 μL/mL,and the MFC of Schisandra rosea oil against Candida albicans was 0.312 5 μL/mL.For the control group (fluconazole) ,the MIC of Schisandra rosea oil against Candida albicans (Monilia albican,Candida tropical) was 0.312 5 μL/mL,and that against Candida krusei was 2.5 mg/mL.The essential oils from five medicinal herbs all showed strong antifungal effect against Candida albicans strains (Monilia albican,Candida tropical,Candida krusei).The antifungal activity was determined in turn as cinnamon bark oil > clove oil > palchouli oil > fennel oil > Schisandra rosea oil.Candida krusei showed drug resistance to fluconazole.[Conclusion]The essential oils extracted from natural medicinal herbs are effective in treating invasive fungal infection caused by Candida albicans,moreover,this does not bring drug resistance to Candida albicans. [Objective] To investigate the antifungal effect of essential oils from 5 medicinal herbs on Candida albicans. [Method] By taken tube disk approach, the essential oils of cinnamon bark, palchouli, clove, fennel and Schisandra rosea were diluted to 2.5-0.019 5 μL / mL by tiraes ratio dilution for MIC and MFC experiments on pathogenic Candida albicans strains (Monilia albican, Candida tropical, Candida krusei) from intestinal tract, lung and kidney. [Results] The MIC and MFC of cinnamon bark oil against Candida albicans were 0.039 and 0.078 μL / mL respectively; those of clove oil against Candida albicans were 0.156 and 0.312 5 μL / mL respectively; those of palchouli oil against Candida albicans were 0.313 and 0.625 μL / mL respectively; those of fennel oil oil against Candida albicans were 0.156 and 0.312 5 μL / mL respectively. The MIC of Schisandra rosea oil against Candida albicans (Monilia albican, Candida krusei) was 0.312 5 μL / mL, that against Candida tropical was 0.625 μL / mL, and t he MFC of Schisandra rosea oil against Candida albicans was 0.312 5 μL / mL. For the control group (fluconazole), the MIC of Schisandra rosea oil against Candida albicans (Monilia albican, Candida tropical) was 0.312 5 μL / mL, and that against Candida krusei was 2.5 mg / mL. The essential oils from five medicinal herbs all showed strong antifungal effect against Candida albicans strains (Monilia albican, Candida tropical, Candida krusei). The antifungal activity was determined in turn as cinnamon bark oil> clove oil> The essential oils extracted from natural medicinal herbs are effective in treating invasive fungal infection caused by Candida albicans, moreover, this does not bring drug resistance to Candida albicans.