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目的探讨CD44~+/CD24~(-/low)表型在三阴性乳腺癌(triple-negative breast cancer,TNBC)中的表达情况及其与三阴性乳腺癌的临床病理特征及预后的关系。方法从青岛市中心医疗集团乳腺癌数据库中筛选出2008年1月至2009年12月53例三阴性乳腺癌病人的石蜡标本,同时随机选取53例同时期相应临床分期的非三阴性乳腺癌(NTNBC)病人的石蜡标本。应用免疫组化技术进行CD44、CD24染色,将CD44~+/CD24~(-/low)表型在两组病人中的表达情况进行统计学分析,探讨其与三阴性乳腺癌的临床病理特征及预后的关系。结果 CD44~+/CD24~(-/low)(+)在TNBC组中为54.71%,明显高于NTNBC组(45.28)(P<0.05)。在TNBC组,临床病理分期Ⅲ期在CD44~+/CD24~(-/low)(+)中有15例(28.30%),高于CD44~+/CD24~(-/low)(-)(9.43%)(P<0.05);局部复发率在CD44~+/CD24~(-/low)(+)和CD44~+/CD24~(-/low)(-)中分别为24.52%和5.66%(P<0.05);远处转移率分别为16.98%和3.77%(P<0.05)。TNBC组中,CD44~+/CD24~(-/low)(+)5年OS(62.00%)、DFS(51.00%)均低于CD44~+/CD24~(-/low)(-)5年OS(80.00%)、DFS(75.00%),两组间的差异有统计学意义。结论 CD44~+/CD24~(-/low)的高表达可能与三阴性乳腺癌的复发、转移及预后差有相关性。
Objective To investigate the expression of CD44 ~ + / CD24 ~ (- / low) phenotype in triple-negative breast cancer (TNBC) and its relationship with the clinicopathological features and prognosis of triple negative breast cancer. Methods The paraffin specimens of 53 patients with triple-negative breast cancer from January 2008 to December 2009 were screened from Qingdao Central Medical Group Breast Cancer Database. At the same time, 53 cases of non-triple-negative breast cancer NTNBC) Patient’s paraffin specimens. The expression of CD44 ~ + / CD24 ~ (- / low) phenotype in two groups of patients was analyzed by immunohistochemistry and CD44, CD24 staining, and the clinical and pathological features of triple negative breast cancer were analyzed. Prognosis of the relationship. Results CD44 ~ + / CD24 ~ (- / low) (+) in TNBC group was 54.71%, which was significantly higher than that in NTNBC group (45.28) (P <0.05). In TNBC group, there were 15 cases (28.30%) in stage Ⅲ of clinical stage of CD14 ~ + / CD24 ~ (+ / low), which was higher than that of CD44 ~ + / CD24 ~ 9.43%) (P <0.05). The local recurrence rates were 24.52% and 5.66% in CD44 + / CD24 ~ (-) low and CD44 ~ + / CD24 ~ (P <0.05). The distant metastasis rates were 16.98% and 3.77% respectively (P <0.05). In the TNBC group, the 5-year OS (62.00%) and DFS (51.00%) of CD44 + / CD24 ~ (- /low)( +) were lower than those of CD44 + / CD24 ~ OS (80.00%), DFS (75.00%), the difference between the two groups was statistically significant. Conclusion The high expression of CD44 ~ + / CD24 ~ (-) / low may be related to the recurrence, metastasis and prognosis of triple negative breast cancer.