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1例16岁女性患者,因神经性厌食服用草酸艾司西酞普兰10 mg,1次/d。服用1个月余,因闭经于外院就诊,查肝功能示丙氨酸转氨酶(ALT)222 U/L,天冬氨酸转氨酶(AST)124 U/L,白蛋白45 g/L。停用草酸艾司西酞普兰,1周后再次使用,同时给予保肝治疗,但无好转,遂入住北京协和医院。入院查肝功能:ALT 3257 U/L,白蛋白37 g/L,总胆红素(TBil)37.7μmol/L,直接胆红素(DBil)21.3μmol/L。停用草酸艾司西酞普兰,给予谷胱甘肽、腺苷蛋氨酸、复方甘草酸苷、多烯磷脂酰胆碱、谷氨酸钠和谷氨酸钾等保肝治疗,2个月后患者肝功能指标恢复正常,出院。
A 16-year-old female patient was given escitalopram oxalate 10 mg once daily for anorexia nervosa. Taking more than 1 month, due to amenorrhea outside the hospital, check liver function showed alanine aminotransferase (ALT) 222 U / L, aspartate aminotransferase (AST) 124 U / L, albumin 45 g / L. Escort Escitalopram disabled, 1 week after the re-use, while giving liver protection treatment, but no improvement, then stay in Peking Union Medical College Hospital. Admission to check the liver function: ALT 3257 U / L, albumin 37 g / L, total bilirubin (TBil) 37.7μmol / L, direct bilirubin (DBil) 21.3μmol / L. Escitalum oxalate deactivation, given glutathione, adenosyl methionine, compound glycyrrhizin, polyene phosphatidylcholine, glutamate and potassium glutamate and other liver protection treatment, 2 months after the patients Liver function returned to normal, discharged.