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目的探讨β-七叶皂甙钠联合乌拉地尔治疗高血压合并脑梗死的临床效果。方法将2010年1月～2011年10月入某院治疗的高血压合并脑梗死患者随机分为对照组和治疗组,对照组患者给予常规治疗,治疗组患者在常规治疗组的基础上用β-七叶皂甙钠和乌拉地尔,连续使用14d,观察两组患者治疗后7d、14d以及随访90d时的临床疗效,比较NIHSS评分和ADL评分以及血清中炎症因子(hs-CRP)的水平。结果治疗两周后治疗组的总有效率为84.37%,显著高于对照组总有效率71.87%,P﹤0.05;治疗前两组患者的NIHSS评分和ADL评分比较差异无统计学意义,P﹥0.05,治疗后7d、14d,90d随访时的NIHSS评分,治疗组均显著低于对照组,ADL评分治疗组均显著高于对照组,P﹤0.05;检测患者血清中hs-CRP水平,治疗前两组患者血清中hs-CRP水平差异无统计学意义,P﹥0.05,疗后7d、14d,90d随访时治疗组均显著低于对照组,P﹤0.05。结论β-七叶皂甙钠联合乌拉地尔治疗高血压合并脑梗死患者,改善神经功能缺损评分和日常生活活动能力评分,并抑制炎症反应,疗效显著。
Objective To investigate the clinical effect of β-aescinate combined with aliskiprad on patients with hypertension and cerebral infarction. Methods Patients with hypertension complicated by cerebral infarction who were admitted to a hospital from January 2010 to October 2011 were randomly divided into control group and treatment group. Patients in control group were given routine treatment. Patients in treatment group were treated with β - sodium aescinate and urapidil for consecutive 14 days. The clinical efficacy at 7d, 14d and 90d after treatment was observed. The NIHSS score, ADL score and serum hs-CRP level were compared between the two groups. Results After two weeks of treatment, the total effective rate of the treatment group was 84.37%, which was significantly higher than that of the control group (71.87%, P <0.05). There was no significant difference in the NIHSS score and ADL score between the two groups before treatment (P> 0.05, the NIHSS score at 7d, 14d and 90d after treatment was significantly lower in the treatment group than in the control group, the ADL score treatment group were significantly higher than the control group, P <0.05; serum hs-CRP levels were detected before treatment There was no significant difference in hs-CRP levels between the two groups (P> 0.05). The levels of serum hs-CRP in the two groups were significantly lower than those in the control group at 7d, 14d and 90d (P <0.05). Conclusion β-aescinate sodium combined with urapidil in patients with hypertension complicated by cerebral infarction, improve neurological deficit scores and activities of daily living score, and inhibit the inflammatory response, the effect is significant.