论文部分内容阅读
目的分析抗菌药物不良反应发生的情况,为临床合理用药提供依据。方法选取2009年3月~2011年5月我院各科室上报的276例抗菌药物不良反应(ADR)统计并分析抗菌药物所致ADR与性别年龄的关系,分析不同给药途径ADR发生的情况,比较各类抗菌药引起的不良反应发生率及对人体系统的损害和临床表现。结果抗菌药物所致ADR中男137例(49.6%),女139例(50.4%),男女例数比较差异无统计学意义(P>0.05);ADR在10岁以下的儿童和50岁以上的老年人中发生率较高,分别为30.1%、39.5%。引起ADR的抗菌药物中,前三位分别为头孢菌素类(约占43.1%)、喹诺酮类(约占25.4%)、林可霉素类(约占14.9%)。结论抗菌药物会引发人体各大系统的损害,医院应该加强抗菌药物的监管,减少抗菌药所致的ADR。
Objective To analyze the occurrence of adverse reactions of antimicrobial agents and provide the basis for clinical rational drug use. Methods A total of 276 cases of ADR reported by various departments of our hospital from March 2009 to May 2011 were collected and analyzed. The relationship between ADR and sex and age due to antibiotics was analyzed. The incidence of ADR in different administration routes was analyzed. Compare the incidence of adverse reactions caused by various antimicrobial agents and the damage to the human body system and clinical manifestations. Results There were 137 (49.6%) males and 139 females (50.4%) females in ADR caused by antimicrobial agents. There was no significant difference in the number of males and females between the two groups (P> 0.05) The incidence of the elderly is higher, respectively 30.1%, 39.5%. The top three antibacterial drugs that cause ADR are cephalosporins (about 43.1%), quinolones (about 25.4%) and lincomycin (about 14.9%). Conclusion Antimicrobial drugs can cause damage to the major systems in the human body. The hospital should strengthen the supervision of antibacterials and reduce the ADR caused by antibacterials.