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作者曾报道,利多卡因在大鼠直肠的平均生物利用度约为口服的15倍。本文进一步通过直肠给予大鼠另一种高清除率药物心得安亦获得相同结果,说明有可能通过直肠途径给药而绕过肝脏。6只雄性Wistar大鼠按平行交叉设计口服和直肠
The authors have reported that the average bioavailability of lidocaine in the rectum of rats is about 15 times higher than that of oral administration. This article further rectal administration of rat another high-clearance drug propranolol also obtained the same result, indicating that it is possible to bypass the liver through the rectal route of administration. Six male Wistar rats were designed for oral and rectal cross-parallelization