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用免疫组织化学（ＡＢＣ）方法结合图象分析和听觉电生理技术研究了冲击波对豚鼠耳蜗血管纹心钠素（ＡＮＰ）的影响及其与听阈阈移的关系。结果表明：冲击彼暴露后６、１２、２４、４８小时组，血管纹中ＡＮＰ－ＩＲ产物的光密度值较７２小时组和对照组明显增高（Ｐ＜０．０１），７２小时与对照组的光密度值无显著差异（Ｐ＞０．０５）。血管纹中ＡＮＰ－ＩＲ光密度值的变化与ＡＢＲ阈移呈正相关。提示，血管纹中的ＡＮＰ含量的增高可能是机体对冲击波所致听力损伤的一种代偿机制；ＡＮＰ在冲击波所致听力损伤中可能起着保护作用。
The effects of shock waves on the blood serum atrial natriuretic Peptide (ANP) in guinea pigs and its relationship with the threshold of hearing threshold were studied by immunohistochemistry (ABC) combined with image analysis and electrophysiological techniques. The results showed that at 6, 12, 24 and 48 hours after shock exposure, the optical density of ANP-IR product in vascular pattern was significantly higher than that in 72 hours and control group (P <0.01) No significant difference in optical density (P> 0.05). The change of ANP-IR optical density in vascular pattern was positively correlated with ABR threshold shift. It is suggested that the increase of ANP content in vascular pattern may be a compensatory mechanism of the body’s hearing damage caused by shock wave; ANP may play a protective role in shock damage caused by shock wave.