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目的对系统性红斑狼疮(SLE)性肝损害病例进行临床分析。方法选取在本院进行治疗的60例SLE患者,分为肝损害组和肝正常组,将两组患者的临床表现、实验室检查及SLE疾病活动指数(SLEDAI)检测结果进行比较。结果肝损害组患者IgG平均水平明显高于与正常组,差异具有统计学意义(P<0.05);SLEDAI结果肝损害组(14.52±8.59)明显高于正常组(11.47±5.91),差异具有统计学意义(P<0.05);处于病情活动期的患者发生肝损害的比率(73.53%)明显高于非活动期患者(26.92%),差异具有统计学意义(P<0.05)。结论 SLE肝损害以IgG升高为特异性表现,且病情活动期SLE患者出现肝损害的比率明显高于非活动期患者,表明肝损害可能为SLE病情活动的表现。
Objective To analyze the clinical data of patients with systemic lupus erythematosus (SLE) liver damage. Methods Sixty patients with SLE treated in our hospital were divided into liver damage group and normal liver group. The clinical manifestations, laboratory tests and SLE disease activity index (SLEDAI) were compared between the two groups. Results The average level of IgG in patients with liver damage was significantly higher than that in normal controls (P <0.05). The results of SLEDAI in liver injury patients (14.52 ± 8.59) were significantly higher than those in normal subjects (11.47 ± 5.91) (P <0.05). The incidence of liver damage in patients with active disease (73.53%) was significantly higher than that in inactive patients (26.92%), the difference was statistically significant (P <0.05). Conclusions The liver damage in SLE is characterized by elevated IgG, and the rate of liver damage in SLE patients with active disease is significantly higher than that in inactive patients, indicating that liver damage may be the manifestation of SLE disease activity.