目的探讨甘露醇激发试验和组胺激发试验对支气管哮喘的临床应用价值。方法 60例支气管哮喘患者,对其进行组胺激发试验,阳性患者再进行甘露醇激发试验,观察其诊断价值。结果甘露醇激发试验的灵敏度为90.9%,误诊率为6.2%,特异度为93.7%,漏诊率为9.1%,组胺激发试验的特异度为88.2%,灵敏度为95.2%,一致检验量Kappa=0.812,差异有统计学意义(P<0.01)。结论与组胺激发试验相比,以甘露醇激发试验对于支气管哮喘患者的特异性更好,是一种既方便又经济的检测手段,具有重要的研究价值与应用前景。 Objective To investigate the clinical value of mannitol provocation test and histamine provocation test on bronchial asthma. Methods Sixty patients with bronchial asthma were subjected to histamine challenge test, and the positive patients were further subjected to mannitol challenge test to observe its diagnostic value. Results The sensitivity of mannitol challenge test was 90.9%, the misdiagnosis rate was 6.2%, the specificity was 93.7%, the misdiagnosis rate was 9.1%, the specificity of histamine challenge test was 88.2% and the sensitivity was 95.2% 0.812, the difference was statistically significant (P <0.01). Conclusion Compared with histamine challenge test, mannitol challenge test is more specific for patients with bronchial asthma. It is a convenient and economical method to detect mannitol and has important research value and application prospect.