树突状细胞在诱导机体免疫耐受中发挥重要的作用。它可调节其表面免疫球蛋白样转录物3和免疫球蛋白样转录物4的表达,抑制T细胞的活化,并形成“抑制性T细胞级联”,还可上调吲哚胺2,3双加氧酶的表达,通过耗竭局部环境中色氨酸抑制T细胞功能。对树突状细胞诱导免疫耐受机制的研究在自身免疫性疾病、慢性感染性疾病、肿瘤和移植排斥反应的防治方面都具有非常重要的意义。 Dendritic cells play an important role in inducing immune tolerance. It regulates the expression of its surface immunoglobulin-like transcript 3 and immunoglobulin-like transcript 4, inhibits T-cell activation and forms “inhibitory T-cell cascades” and also upregulates indoleamine 2,3-bis The expression of oxygenase inhibits T cell function by depleting tryptophan in the local environment. Research on the mechanism of dendritic cell-induced immune tolerance is of great importance in the prevention and treatment of autoimmune diseases, chronic infectious diseases, tumors and transplant rejection.