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邻甲苯胺经口半数致死量为７５５ｍｇ／ｋｇ，属低毒类。动物染毒邻甲苯胺１９ｍｇ／ｋｇ以上引起小鼠脾脏增大，３８ｍｇ／ｋｇ以上引起白细胞计数升高，且淋巴细胞百分比升高，各染毒剂量对小鼠血清免疫球蛋白ＩｇＧ含量和巨噬细胞吞噬功能无明显影响。结果表明，邻甲苯胺对适血系统（包括脾脏）有影响，对免疫系统无明显直接影响。
Oral toluidine oral half lethal dose of 755mg / kg, is a low-toxic. Animal poisoning o-toluidine 19mg / kg or more caused by the spleen of mice increased above 38mg / kg caused by increased white blood cell count, and the percentage of lymphocytes increased, the dose of each dose of serum IgG immunoglobulin and macrophage No significant effect of phagocytosis. The results showed that o-toluidine on the hematopoietic system (including the spleen) have no effect on the immune system.